Majma Uz Zawaid Urdu Pdf 23
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majma uz zawaid urdu pdf download
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Many of the blood components of the coagulation cascade are present in our extracellular environment, where they play an important role in homeostasis. Platelets are a key component of the coagulation cascade and are involved in haemostasis. Many studies have implicated excessive platelet activation in the genesis of thrombotic vascular disorders such as restenosis. Activated platelets are also a significant risk factor in atherosclerotic disease, as well as tumour growth. The vast majority of cancer cells are initially derived from blood-derived endothelial cells. It is known that endothelial cells possess the machinery to generate platelets, which may be further activated to release cytokines and growth factors that regulate the growth and survival of blood vessel tumour cells. One strategy to treat tumours is to inhibit platelet function. This can be achieved by inhibiting the platelet GPIIb/IIIa receptor or by blocking agonists, such as ADP. A number of high affinity antagonists have been reported which are useful for blocking the platelet GPIIb/IIIa receptor, for example, Arg-Gly-Asp (RGD), NAP-2, GRGDS, and for inhibiting platelet activation, for example, Epinephrine, Thrombin, ADP, Thromboxane A2, Collagen, and Ibis Ind 0b46394aab
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